Antigenic Hepatitis A Virus Structures May Be Produced in Escherichia coli

AUTOR(ES)

Sánchez, Glòria

FONTE

American Society for Microbiology

RESUMO

The synthesis of 14S pentamers and 70S empty capsids of hepatitis A virus (HAV) has been accomplished by expressing the viral genome for periods of time longer than 4 h in Escherichia coli. HAV pentamers (14S) self-assembled into capsids (70S) in vitro. The antibodies induced by these structures recognized and neutralized HAV.

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