Antimalarial Activities of Aminooxy Compounds
AUTOR(ES)
Berger, Bradley J.
FONTE
American Society for Microbiology
RESUMO
Twenty-three aminooxy compounds have been examined for their ability to inhibit the growth of the malaria parasite Plasmodium falciparum in vitro. Eight of these compounds were found to have 50% inhibitory concentrations less than 10 μM, with the best drugs being canaline (the aminooxy analogue of ornithine) and CGP51905A at 297 ± 23.6 nM and 242 ± 18.8 nM, respectively. Canaline was also assayed in combination with the ornithine decarboxylase inhibitor difluoromethylornithine, and the two drugs were found to be synergistic in antimalarial activity.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=90101Documentos Relacionados
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