Antimicrobial Activities of Amine- and Guanidine-Functionalized Cholic Acid Derivatives

AUTOR(ES)

Li, Chunhong

FONTE

American Society for Microbiology

RESUMO

Compounds in a series of cholic acid derivatives, designed to mimic the activities of polymyxin B and its derivatives, act as both potent antibiotics and effective permeabilizers of the outer membranes of gram-negative bacteria. Some of these compounds rival polymyxin B in antibacterial activity against gram-negative bacteria and are also very active against gram-positive organisms. Other compounds interact synergistically with hydrophobic antibiotics to inhibit bacterial growth.

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