Antimicrobial susceptibility of Campylobacter jejuni with special reference to resistance patterns of Canadian isolates.
AUTOR(ES)
Karmali, M A
RESUMO
Agar dilution antimicrobial susceptibility testing of Camphylobacter jejuni showed that erythromycin, clindamycin, nitrofurantoin, and gentamicin were the most active compounds, inhibiting 90% of the isolates at a concentration of 1 microgram/ml or less. The frequency of high-level erythromycin resistance was 1%. Erythromycin-resistant isolates showed cross-resistance to clindamycin. All strains were inhibited by chloramphenicol at less than or equal to 8 micrograms/ml. About 20% of the isolates were resistant to tetracycline at 4 micrograms/ml. All strains were highly resistant to novobiocin, bacitracin, vancomycin, and trimethoprim and resistant to rifampin. The minimal inhibitory concentrations (MICs) of metronidazole ranged from less than or equal to 0.5 to 128 micrograms/ml. The susceptibility of strains to sulfamethoxazole and polymyxin B sulfate was markedly influenced by inoculum size. The MICs of polymyxin B sulfate were significantly higher at 42 than 36 degrees C. All strains were inhibited by nalidixic acid at 32 micrograms/ml. In the penicillin group, ampicillin was the most active compound, inhibiting only about three-quarters of the strains at 8 micrograms/ml. The cephalosporins as a group showed only moderate to poor activity, the most active cephalosporin being cefotaxime, which inhibited about 90% of the strains at 8 micrograms/ml. The use of antibiotics in selective media is discussed.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=181484Documentos Relacionados
- Antimicrobial resistance of Campylobacter jejuni and Campylobacter coli with special reference to plasmid profiles of Japanese clinical isolates.
- Antimicrobial susceptibility of Campylobacter jejuni and Campylobacter fetus subsp. fetus to eight cephalosporins with special reference to species differentiation.
- Susceptibility of clinical isolates of Campylobacter jejuni to sixteen antimicrobial agents.
- Comparison of antimicrobial susceptibility patterns of Campylobacter jejuni and Campylobacter coli.
- Incidence of Antibiotic Resistance in Campylobacter jejuni Isolated in Alberta, Canada, from 1999 to 2002, with Special Reference to tet(O)-Mediated Tetracycline Resistance