Antimycobacterial and cytotoxicity activity of synthetic and natural compounds
AUTOR(ES)
Souza, Ana O. de, Galetti, Fabio C. S., Silva, Célio L., Bicalho, Beatriz, Parma, Márcia M., Fonseca, Sebastião F., Marsaioli, Anita J., Trindade, Angela C. L. B., Gil, Rossimíriam P. Freitas, Bezerra, Franciglauber S., Andrade-Neto, Manoel, Oliveira, Maria C. F. de
FONTE
Química Nova
DATA DE PUBLICAÇÃO
2007
RESUMO
Antimycobacterial and cytotoxicity activity of synthetic and natural compounds. Secondary metabolites from Curvularia eragrostidis and Drechslera dematioidea, Clusia sp. floral resin, alkaloids from Pilocarpus alatus, salicylideneanilines, piperidine amides, the amine 1-cinnamylpiperazine and chiral pyridinium salts were assayed on Mycobacterium tuberculosis H37Rv. N-(salicylidene)-2-hydroxyaniline was the most effective compound with a minimal inhibitory concentration (MIC) of 8 µmol/L. Dihydrocurvularin was moderately effective with a MIC of 40 µmol/L. Clusia sp. floral resin and a gallocatechin-epigallocatechin mixture showed MIC of 0.02 g/L and 38 µmol/L, respectively. The cytotoxicity was evaluated for N-(salicylidene)-2-hydroxyaniline, curvularin, dihydrocurvularin and Clusia sp. floral resin, and the selectivity indexes were > 125, 0.47, 0.75 and 5, respectively.
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