Antimycobacterial Calixarenes Enhance Innate Defense Mechanisms in Murine Macrophages and Induce Control of Mycobacterium tuberculosis Infection in Mice
AUTOR(ES)
Colston, M. Joseph
FONTE
American Society for Microbiology
RESUMO
Tuberculosis remains the leading cause of death among infectious diseases, accounting for more than two million deaths annually. The incidence of the disease is increasing globally, partially because of the resurgence of drug-resistant strains of Mycobacterium tuberculosis. Calixarenes are macrocyclic oligomers, some of which are able to modify the growth of M. tuberculosis in infected cells. Most experimental work has been carried out with Macrocyclon, also known as HOC 12.5EO. In this study, we demonstrate that Macrocyclon is effective in controlling M. tuberculosis infections, and we provide evidence that its effect is partially mediated by an l-arginine-dependent mechanism of macrophage activation that involves the activity of the inducible nitric oxide synthase. We also show that Macrocyclon is effective in athymic and major histocompatibility complex class II−/− mice and synthesized a number of structurally related calixarenes expressing significant antimycobacterial activity.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=523005Documentos Relacionados
- Defense mechanisms against infectious bovine rhinotracheitis virus: inhibition of virus infection by murine macrophages.
- Arabinofuranosyl-terminated and mannosylated lipoarabinomannans from Mycobacterium tuberculosis induce different levels of interleukin-12 expression in murine macrophages.
- CpG Oligodeoxynucleotides Enhance Host Defense during Murine Tuberculosis
- Survival of Mycobacterium avium and Mycobacterium tuberculosis in Acidified Vacuoles of Murine Macrophages
- Multigenic Control of Disease Severity after Virulent Mycobacterium tuberculosis Infection in Mice