Antipsychotic Drugs and Dopamine-Stimulated Adenylate Cyclase Prepared from Corpus Striatum of Rat Brain
AUTOR(ES)
Karobath, M.
RESUMO
Antipsychotic drugs and their clinically impotent congeners were examined as inhibitors of dopamine-sensitive adenylate cyclase (EC 4.6.1.1) in cell-free membrane preparations of the caudate-putamen of rat brain. Of 12 neuroleptic drugs with reported antipsychotic efficacy, all inhibit stimulation of adenylate cyclase by 40 μM dopamine at micromolar concentrations. Among 14 other structurally related drugs that are not clinically effective as antipsychotic agents, 12 were almost ineffective while two drugs were moderate inhibitors of dopamine-sensitive adenylate cyclase.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=388584Documentos Relacionados
- Enhancement of Dopamine-Stimulated Adenylate Cyclase Activity in Rat Caudate after Lesions in Substantia Nigra: Evidence for Denervation Supersensitivity
- Agonist-induced subsensitivity of adenylate cyclase coupled with a dopamine receptor in slices from rat corpus striatum.
- Dopamine-Sensitive Adenylate Cyclase in Mammalian Brain: A Possible Site of Action of Antipsychotic Drugs
- Quantitative determination of dopamine receptor subtypes not linked to activation of adenylate cyclase in rat striatum.
- Dopamine-Sensitive Adenylate Cyclase in Caudate Nucleus of Rat Brain, and Its Similarity to the “Dopamine Receptor”