AP1 enhances polyomavirus DNA replication by promoting T-antigen-mediated unwinding of DNA.
AUTOR(ES)
Guo, W
RESUMO
An early step in the initiation of polyomavirus DNA replication is viral large-T-antigen-mediated unwinding of the origin. We report that components of the AP1 transcription factor, Fos and Jun, interact with T antigen in vitro to enhance unwinding of the viral origin. This provides a biochemical basis for the capacity of AP1 to activate viral DNA replication in vivo.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=190441Documentos Relacionados
- Analysis of an activatable promoter: sequences in the simian virus 40 late promoter required for T-antigen-mediated trans activation.
- Amplification mediated by polyomavirus large T antigen defective in replication.
- High-frequency recombination mediated by polyomavirus large T antigen defective in replication.
- Multiple binding sites for polyomavirus large T antigen within regulatory sequences of polyomavirus DNA.
- Polyomavirus small T antigen enhances replication of viral genomes in 3T6 mouse fibroblasts.
