Aplysfistularine: a novel dibromotyrosine derivative isolated from Aplysina fistularis
AUTOR(ES)
Lira, Narlize Silva, Monte-Neto, Rubens L., Marchi, João Guilherme B., Lins, Antônio Cláudio da Silva, Tavares, Josean Fechine, Silva, Marcelo Sobral da, Dias, Celidarque da Silva, Barbosa-Filho, José Maria, Santos, Creusioni Figueredo dos, Cunha, Emídio Vasconcelos Leitão da, Pinheiro, Ulisses dos Santos, Braz-Filho, Raimundo
FONTE
Quím. Nova
DATA DE PUBLICAÇÃO
2012
RESUMO
The new dibromotyrosine derivative 3,5-dibromo-4-[3'dimethylamonium]propoxyphenyl]-N,N,N-trimethylethanamonium, here referred to as aplysfistularine (1), was isolated from the marine sponge Aplysina fistularis along with 2-(3,5-dibromo-4methoxyphenyl)-N,N,N-trimethylethanamonium (2), aplysterol (3) and 24,28-didehydroaplysterol (4). Their identification was performed by mass spectrometry, infrared, ¹H and 13C NMR, and by comparison with literature data. Compound 2 and the mixture of 3 and 4 were tested in vitro (inhibitory activity) with supercoiled DNA relaxation techniques, and showed inhibitory activity on human DNA topoisomerase II-α. Compound 1 was not tested due to paucity of the material.
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