Are there diurnal fluctuations in crypt length and crypt cell birth rate in the intestines of normal and carcinogen-treated rats?
AUTOR(ES)
Senior, P V
RESUMO
At eight time points over a period of 24 hours, crypt length (in cells) and crypt cell birth rate were measured by the stathmokinetic method with vincristine and evaluated at two sites in the small intestine and two in the colon in Wistar Porton rats. Normal animals were compared with animals which had received 24 injections, at weekly intervals, of the intestinal carcinogen 1,2-dimethylhydrazine. In the treated animals, crypts were significantly longer at sites prone to tumour formation but not at those sites known to be resistant to the effects of the carcinogen. In neither group of animals was there any significant fluctuation in mean crypt length over a 24 hours period. Crypt cell birth rates showed a considerable fluctuation. No difference was noted between normal animals and those treated with dimethylhydrazine and statistical analysis failed to confirm the presence of any true periodic fluctuation.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1165065Documentos Relacionados
- Carcinogen-induced DNA amplification in vitro: overreplication of the simian virus 40 origin region in extracts from carcinogen-treated CO60 cells.
- Induction of circles of heterogeneous sizes in carcinogen-treated cells: two-dimensional gel analysis of circular DNA molecules.
- DIURNAL FLUCTUATIONS OF GROWTH IN LENGTH OF TOMATO STEM
- Can intraurethral stimulation inhibit micturition reflex in normal female rats?
- Dorsal root potentials are unchanged in adult rats treated at birth with capsaicin.