Arginine-Glycine-Aspartic Acid Motif Is Critical for Human Parechovirus 1 Entry
AUTOR(ES)
Boonyakiat, Yingmanee
FONTE
American Society for Microbiology
RESUMO
The human parechovirus 1 RGD motif in VP1 was studied by mutagenesis. An RGD-to-RGE change gave only revertant viruses with a restored RGD, while deletion of GD was lethal and nonrevertable. Mutations at the +1 and +2 positions had some effect on growth properties and a +1 M-to-P change was lethal. These studies indicate that the RGD motif plays a critical role in infectivity, presumably by interacting with integrins, and that downstream amino acids can have an influence on function.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=114574Documentos Relacionados
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