Arterial stiffness and baroreflex sensitivity in individuals with type 2 diabetes / "A rigidez arterial e o barorreflexo em diabéticos do tipo 2"

AUTOR(ES)
DATA DE PUBLICAÇÃO

2003

RESUMO

Fourteen normotensive diabetic subjects were submitted to carotid-femoral (CF) and carotid-radial (CR) pulse wave velocity (PWV) analysis by non-invasive automatic device. The baroreflex sensitivity (BRS) was evaluated by Valsalva manoeuvre, phenylephrine and nitroglycerin tests during non-invasive beat-to-beat blood pressure monitoring. The data were compared with those obtained in 13 age, body mass index and sex-matched healthy subjects. The diabetes group showed a higher fasting glucose level and HbA1c. The CF PWV and CR PWV were higher in diabetic patients. The BRS was impaired in diabetic individuals in nitroglycerine and phenylephrine tests and, also, in the tachycardic reflex in phase II of Valsalva manoeuvre. The increase of CF PWV was significantly correlated to the decrease of BRS. The data demonstrated that, in diabetic normotensive individuals, arterial stiffness is increased and the BRS is impaired. The BRS is inverselly correlated to increase of aortic stiffness

ASSUNTO(S)

compliance diabetes mellitus nÃo insulino-dependente/complicações barorreflexo complacÊncia diabetes mellitus type ii/complications baroreflex

ACESSO AO ARTIGO

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