Aspectos morfometricos e estererometricos do aumento gengival induzido pela ciclosporina
AUTOR(ES)
Luis Carlos Spolidorio
DATA DE PUBLICAÇÃO
1996
RESUMO
Cycloporin is a selective immunosuppressant, used in organ transplants to prevent graft rejection. Csa can cause various side effects including gingival overgrowth. The aim of this work was to evaluate the gingival overgrowth of rats treated daily with 10mg/kg of body weight of csa, during 60 days, subcutaneosly, as well as the regression of gingival overgrowth after the interruption of treatment. The efects of a cariogenic diet and xerostomia were also considered. All rats treated with csa developed gingival overgrowth, with increased thickness of the epithelium, height and wideness of the connective tissue. The density of fibroblasts and collagen fibers, also increased. The cariogenic diet and xerostomia did not modify the characteristics of the gingiva of either normal and csa treated rats 5 to 90 days after the interruption of treatment with cyclosporin, there was a progressive reduction of the gingival volume and of collagen fibers and fibroblasts densities. The reduction was more exuberant in the initial periods, but after 90 days did not return to the normal values
ASSUNTO(S)
ACESSO AO ARTIGO
http://libdigi.unicamp.br/document/?code=vtls000115026Documentos Relacionados
- Avaliação do crescimento gengival induzido por ciclosporina -A e tacrolimus em i ndivíduos transplantados renais: estudo prospectivo
- AUMENTO GENGIVAL ASSOCIADO À CICLOSPORINA EM TRANSPLANTADOS RENAIS NO HUSM
- Eventos moleculares associados ao aumento gengival induzido por ciclosporina A são atenuados pela superexpressão de Smad7
- Análise epidemiológica do aumento gengival induzido por nifedipina e fenitoína em usuários da Atenção Primária à Saúde
- Hiperplasia gengival induzida por ciclosporina A