Associação do polimorfismo -174g>c no gene da interleucina 6 com angina pectoris / Interleukin 6; Polymorphism; Cardiovascular Disease; Angina Pectoris

AUTOR(ES)
FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

29/04/2011

RESUMO

Interleukin 6 (IL6) is a proinflammatory cytokine that participates in the worsening of cardiovascular diseases (CVD). The polymorphism in position -174 of the IL6 gene involves a change of a single base G to C and it is involved with transcriptional regulation of this cytokine. However, the association of this polymorphism in patients with angina pectoris is unclear. Therefore, this study aims to evaluate the polymorphism-174G>C in IL6 in patients with angina in the region of Vitória - ES. This study was approved by the Ethics and Research of Federal University of Espirito Santo (CEP-UFES). A total of 143 patients were recruited, submitted to evaluation of cardiovascular parameters and separated into two groups: non-angina (n=71) and angina (n=72) and genotyped for the region -174G>C in IL6 gene, through the techniques PCR-RFLP, in GG, GC and CC genotypes. Statistical analysis were performed through student t test, one way anova, chi-square, multiple logistic regression and odds ratios (OR), as appropriated. There were no differences between groups when typical risk factors for CVD were compared. The GG genotype showed a frequency 18% lower in angina group when compared with the non-angina group, while the polymorphism (GC + CC) was 18% higher in patients with angina group compared to non-angina group (p=0.03). Additionally, patients carrying the C allele showed a 2-fold increased risk for developing angina pectoris when compared with those carrying the G allele (OR = 2.02, 95% CI: 1.04 - 3.94), suggesting that polymorphism in the gene IL6 is an independent factor for predisposition to angina. These results support the hypothesis that the polymorphism-174G>C in IL6 gene seems to be involved manifestation of angina pectoris

ASSUNTO(S)

interleucina 6 doença cardiovascular angina pectoris bioquimica dos microorganismos polimorfismo

ACESSO AO ARTIGO

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