Association between schizophrenia and homozygosity at the dopamine D3 receptor gene.
AUTOR(ES)
Crocq, M A
RESUMO
Disturbances in dopamine neurotransmission have been postulated to underlie schizophrenia. We report data from two independent studies of a BalI polymorphism in the dopamine D3 receptor gene in patients with schizophrenia. In both studies, more patients than controls were homozygous (p = 0.005, p = 0.008). When pooled data were analysed, this difference was highly significant (p = 0.0001) with a relative risk of schizophrenia in homozygotes of 2.61 (95% confidence intervals 1.60-4.26).
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1016201Documentos Relacionados
- Association between schizophrenia and homozygosity at the dopamine D3 receptor gene.
- Excess of homozygosity at the dopamine D3 receptor gene in schizophrenia not confirmed.
- Homozygosity at the dopamine D3 receptor locus is not associated with schizophrenia.
- Association between alcoholism and the dopamine D4 receptor gene.
- The dopamine D3 receptor gene: no association with bipolar affective disorder.