Association of type II immunoglobulin G-binding protein expression and survival of group A streptococci in human blood.

AUTOR(ES)

Raeder, R

RESUMO

Expression of immunoglobulin G (IgG)-binding proteins on group A streptococcus strain 64 was monitored on bacteria subjected to sequential passage in human blood. After approximately 10 cycles through human blood, strain 64 demonstrated enhanced levels of IgG-binding protein, including the expression of a type IIa binding molecule with an M(r) of approximately 47,000 present only at very low levels on the parent isolate. Changes in the expression of IgG-binding proteins after passage in human blood were similar to those observed when the same organism was passaged sequentially intraperitoneally in mice. Strain 64, passaged in human blood 23 times, was found to be more virulent than the parent isolate when used to infect mice either intraperitoneally or in a skin air sac. These findings suggest that the expression of IgG-binding proteins may be a common response of group A organisms to pressures exerted by distinct host defense mechanisms.

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