Astrovirus Induces Diarrhea in the Absence of Inflammation and Cell Death
AUTOR(ES)
Koci, Matthew D.
FONTE
American Society for Microbiology
RESUMO
Astroviruses are a leading cause of infantile viral gastroenteritis worldwide. Very little is known about the mechanisms of astrovirus-induced diarrhea. One reason for this is the lack of a small-animal model. Recently, we isolated a novel strain of astrovirus (TAstV-2) from turkeys with the emerging infectious disease poult enteritis mortality syndrome. In the present studies, we demonstrate that TAstV-2 causes growth depression, decreased thymus size, and enteric infection in infected turkeys. Infectious TAstV-2 can be recovered from multiple tissues, including the blood, suggesting that there is a viremic stage during infection. In spite of the severe diarrhea, histopathologic changes in the intestine were mild and there was a surprising lack of inflammation. This may be due to the increased activation of the potent immunosuppressive cytokine transforming growth factor beta during astrovirus infection. These studies suggest that the turkey will be a useful small-animal model with which to study astrovirus pathogenesis and immunity.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=229260Documentos Relacionados
- Critical roles of TRAIL in hepatic cell death and hepatic inflammation
- Programmed cell death and Bcl-2 protection in the absence of a nucleus.
- Astrovirus-associated diarrhea among Guatemalan ambulatory rural children.
- Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK
- Aspergillus antigen induces robust Th2 cytokine production, inflammation, airway hyperreactivity and fibrosis in the absence of MCP-1 or CCR2