Asymptomatic Infection of Adult Volunteers with a Temperature Sensitive Mutant of Mycoplasma pneumoniae
AUTOR(ES)
Greenberg, Harry
RESUMO
Temperature sensitive mutants of Mycoplasma pneumoniae were developed with the expectation that their temperature sensitive defects would restrict replication in vivo at the temperature of the lower respiratory tract, whereas such defects would not seriously impair replication in the cooler environment of the upper respiratory passages. One such ts mutant, ts-H43, which does not replicate at a temperature of 37° or above, although noninfectious for hamsters, infected each of 16 seronegative adult volunteers when given by the intranasal route. The mutant remained genetically stable throughout the course of infection and stimulated a moderate systemic and local antibody response. The mutant was entirely avirulent for the volunteers but appeared to stimulate resistance to subsequent challenge with partially attenuated wild-type (ts+) Mycoplasma pneumoniae.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=434318Documentos Relacionados
- Temperature-sensitive mutants of influenza A virus: evaluation of the A/Victoria/75-ts-1A2 temperature-sensitive recombinant virus in seronegative adult volunteers.
- Infection of human peripheral blood mononuclear cells with a temperature-sensitive mutant of measles virus.
- Asymptomatic respiratory tract infection with Chlamydia pneumoniae TWAR.
- Process of Infection with Bacteriophage φX174: XXIV. New Type of Temperature-sensitive Mutant
- Mycoplasma pneumoniae Vaccine: Antigenicity of Buffered Antigens in Volunteers