Atividade dos flavonóides rutina e naringina sobre o tumor ascítico de Ehrlich in vivo / Effect the flavonoids rutin and naringin on the Ehrlich ascitic tumor in vivo

AUTOR(ES)

Hussen Machado

DATA DE PUBLICAÇÃO

2006

RESUMO

The present research is evalvating the flavonóids rutin and naringin effect in the prevention and treatment on the Ehrlich ascitic tumor; with the intention of having a better understernding of the viability of tumor cells, sanguine parameters and animals life. To evaluate the preventive effect of flavonoid on the the Ehrlich ascitic tumor, the animals were medicated, through an oral way, with 10mg/kg of flavonoid for 20 days. In the 21st day the animals were inoculated with 1,66 x 104 cel/100 μL in PBS pH 7,4 in an intraperitoneal way. The treatment with flavonoids was interrupted in the same day. After 18 days of the tumor cell inoculation, the animals were submitted to euthanasia and respectives corporal fluid was collected for analyze. To evaluate the effect of flavonoid treatment on the the Ehrlich ascitic tumor, in the 1st experimental day the animals were inoculated with 1,66 x 104 cel/100 μL in PBS pH 7,4, in a intraperitoneal way. Twenty-four hours after the inoculation the treatment started with the flavonoids in a proportiur of 10mg/kg; Then, 18 days after the use of flavonóids, the animals were submitted to euthanasia and respectives corporal fluid was collected for analyze. To have a positive control, Neotaxel was used as a medication. The median survival time of the animals (MST) and the increased percentage of this survival (%ILS) was evaluated a during 30 day period.

ASSUNTO(S)

tumor ascítico câncer flavonóides flavonoids ascitic tumor bioquimica cancer

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