ATM and ATR make distinct contributions to chromosome end protection and the maintenance of telomeric DNA in Arabidopsis

AUTOR(ES)

Vespa, Laurent

FONTE

Cold Spring Harbor Laboratory Press

RESUMO

Here we examine the function of ATM and ATR at telomeres in Arabidopsis. Although plants lacking ATM or ATR display wild-type telomere length homeostasis, chromosome end protection is compromised in atm atr mutants. Moreover, atm tert Arabidopsis experience an abrupt, early onset of genome instability, arguing that ATM is required for protection of short telomeres. ATR, by contrast, is required for maintenance of telomeric DNA as telomere shortening is dramatically accelerated in atr tert mutants relative to tert plants. Thus, ATM and ATR make essential and distinct contributions to chromosome end protection and telomere maintenance in higher eukaryotes.

Documentos Relacionados

• Ku is required for telomeric C-rich strand maintenance but not for end-to-end chromosome fusions in Arabidopsis
• Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells
• Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases
• Telomeric armor: the layers of end protection
• The Telomeric Protein TRF2 Binds the ATM Kinase and Can Inhibit the ATM-Dependent DNA Damage Response