Augmentation of lymphocyte cytotoxicity by antibody to herpesvirus saimiri associated antigens.
AUTOR(ES)
Prevost, J
RESUMO
Sera from owl monkeys infected with Herpesvirus saimiri (HVS) mediated antibody-dependent lymphocyte cytotoxicity (ADLC) against virus-infected owl monkey kidney cells. Peripheral blood lymphocytes from rhesus monkeys served as effector cells in this cytotoxic assay. ADLC titers increased along with membrane immunofluorescence (MF) titers but among some sera, the ADLC titers were much higher than expected from the MF titers, suggesting that multiple serum factors were involved in mediating ADLC in this system. Absorption of both low and high titered sera with HVS-infected owl monkey kidney cells removed all ADLC activity. Preliminary results from serial serum samples from two infected monkeys that developed leukemia and/or lymphoma demonstrated that ADLC but not MF titers increased to high titers with progression of disease and followed essentially a different kinetic pattern than that noted by MF. The possible significance of these findings in relation to malignant disease induced by this virus is discussed.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=432605Documentos Relacionados
- Solubilization and characterization of Herpesvirus saimiri-induced membrane antigens.
- Specificity of the blastogenic response of human mononuclear cells to herpesvirus antigens.
- Goat serums for fluorescent antibody conjugates to chlamydial antigens.
- Response of sensitized and unsensitized human lymphocyte subpopulations to Plasmodium falciparum antigens.
- Role of Cellular Tumor Necrosis Factor Receptor-Associated Factors in NF-κB Activation and Lymphocyte Transformation by Herpesvirus Saimiri STP