Autoantibodies to Brain Components and Antibodies to Acinetobacter calcoaceticus Are Present in Bovine Spongiform Encephalopathy
AUTOR(ES)
Tiwana, Harmale
FONTE
American Society for Microbiology
RESUMO
Bovine spongiform encephalopathy (BSE) is a neurological disorder, predominantly of British cattle, which belongs to the group of transmissible spongiform encephalopathies together with Creutzfeldt-Jakob disease (CJD), kuru, and scrapie. Autoantibodies to brain neurofilaments have been previously described in patients with CJD and kuru and in sheep affected by scrapie. Spongiform-like changes have also been observed in chronic experimental allergic encephalomyelitis, at least in rabbits and guinea pigs, and in these conditions autoantibodies to myelin occur. We report here that animals with BSE have elevated levels of immunoglobulin A autoantibodies to brain components, i.e., neurofilaments (P < 0.001) and myelin (P < 0.001), as well as to Acinetobacter calcoaceticus (P < 0.001), saprophytic microbes found in soil which have sequences cross-reacting with bovine neurofilaments and myelin, but there were no antibody elevations against Agrobacterium tumefaciens or Escherichia coli. The relevance of such mucosal autoantibodies or antibacterial antibodies to the pathology of BSE and its possible link to prions requires further evaluation.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=97071Documentos Relacionados
- EMBRYO TRANSFER AND BOVINE SPONGIFORM ENCEPHALOPATHY (BSE)
- Bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease
- Kinetochore components recognized by human autoantibodies are present on mononucleosomes.
- Oral infection by the bovine spongiform encephalopathy prion
- Genetic and environmental factors modify bovine spongiform encephalopathy incubation period in mice