AvaliaÃÃo da aÃÃo da laserterapia nÃo cirÃrgica em modelo experimental induzido por cacinÃgeno quÃmico

AUTOR(ES)

Aguida Cristina Gomes Henriques

DATA DE PUBLICAÇÃO

2009

RESUMO

Low energy laser promotes therapeutic effects and morfodifferentiation and cell proliferation alterations. Its action in the proliferative activity is a controversial subject because studies show inhibition, proliferation or indifference regarding the cellular growth. In fact, the proliferation of normal and tumoral cells can be stimulated, but this process depends on the light parameters and on the cellular proliferation curve in the moment of the irradiation. Itâs considered that the malignant cells are more susceptive to the proliferative inductor process because it presents modifications in the proliferation and differentiation capacity. This is an important research area being developed, mainly when it is considered the safety and effectiveness of the lasertherapy. Thus, the objective of this work was to evaluate the capacity of 660 and 780nm low intensity laser in increasing the epithelial alterations severity induced by experimental carcinogenesis. Sixty Wistar rats were divided into six groups. One group received just carcinogen solution; three groups received carcinogen solution and laser irradiation; and the others two groups were submitted only to laser irradiation. The 4-Nitroquinoline 1- Oxide (4NQO) application was performed during the maximum period of four months and with the use of a brush on the right side of the animal tongue. The results showed that the laser did not contribute positively with the initial process of the experimental oral carcinogenesis. Also, the produced epithelial alterations did not show differences in clinical and histological aspects between the group that only received carcinogen solution and the groups that received carcinogen solution and laser irradiation.

ASSUNTO(S)

carcinoma espinocelular odontologia squamous cell carcinoma proliferaÃÃo celular lasertherapy cell proliferation laserterapia

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