Avaliação da influência de tensoativos na pele de muda de cobra (Bothrops jararaca e Spilotis pullatus) por espectroscopia fatoacústica no infravermelho, calorimetria exploratória diferencial e espectroscopia Raman / Evaluation of the influence of surfactants on the stratum corneum of shed snake skin (Bothrops jararaca and Spilotis pullatus) by photoacoustic spectroscopy, differential scanning calorimetry and Raman spectroscopy

AUTOR(ES)
DATA DE PUBLICAÇÃO

2004

RESUMO

The influence of the surfactants sodium lauryl sulfate, cetyl trimethyl ammonium chloride and lauryl alcohol ethoxylate (12 moles ethylene oxide) was evaluated on the stratum corneum of shed snake skin (Bothrops jararaca and Spilotis pullatus) through the biophysical techniques PAS-FTIR, FT-Raman and DSC. The surfactants were used in solutions above and below the cmc and the stratum corneum samples were pre-treated for periods of 4 and 8 hours (whole stratum corneum) and for 12 hours (stratum corneum after tape stripping procedure). The presence of the surfactants sodium lauryl sulfate and cetyl trimetyl ammonium chloride could be detected in the stratum corneum and the main change promoted by both was the increase of the water content of the membrane; the lauryl alcohol ethoxylate (12 moles ethylene oxide) did not promote increase in the hydration but showed some action as far as lipid extraction. The tape stripping procedure showed to be useful for the treatment of the stratum corneum of shed snake skin, making the membrane more adequate than the whole stratum corneum for the studies of the action of permeation enhancers.

ASSUNTO(S)

promotor de permeação shed snake skin tensoativos (aplicações; avaliação) medicamento (avaliação) espectros (aplicações) permeation enhancer surfactants pele de muda de cobra

ACESSO AO ARTIGO

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