Avaliação do potencial metastático e da vascularização nas neoplasias epiteliais de glândulas salivares.

AUTOR(ES)
DATA DE PUBLICAÇÃO

2007

RESUMO

Tumoral angiogenesis represents a potential bimolecular marker for prognosis and predictive factor for metastasis in human solid tumors. Recently, endothelial markers and growth vascular factors such as the vascular endothelial growth factor (VEGF) and the platelet derived endothelial growth factor (PDEGF), as well as the vascular endothelial markers CD34 and CD105 have been employed to evaluate the distribution and to quantify of angiogenesis. The objective of this study was to perform morpho-histogenetic, quantitative and semi-quantitative analysis of the immunohistochemical expression of VEGF, PDEGF, CD34, and CD105 in primary epithelial salivary gland tumors, as well as compare this expression with the biological behavior of those neoplasms as determined by the existence (pm) or absence (pnm) of metastasis. In this sense, it was selected 139 cases of epithelial salivary gland tumors diagnosed and treated in the Brazilian National Cancer Institute (INCA), placed in Rio de Janeiro City (RJ), from 1997 to 2003, consisting in 30 pleomorphic adenomas (PA), 19 polymorphic low grade adenocarcinoma (PLGA), 50 adenoid cystic carcinoma (ACC) and 40 of mucoepidermoid carcinoma (MEC). Statistic significant difference (p <0.05) was found between: 1) PA and the group of primary malignant lesions (Pmalig) for VEGF (p <0.0001), PDEGF (p = 0.006), CD34 (p = 0.003) and CD105 (p = 0.003); 2) PLGA, ACC and MEC for PDEGF (p <0.0001), CD34 (p <19 0.0001) and CD105 (p <0.0001), where the difference occurred between MEC and PLGA, and MEC and ACC. The comparison between pm and pnm for each histological type and for each malignant group did not reveal significant differences. In conclusion, the present results suggest that VEGF, PDEGF, CD34 and CD105 do not represent good predictors for metastasis and prognosis in epithelial salivary gland tumors, albeit they may reflect some pathogenetic differences among specific groups of these neoplasms.

ASSUNTO(S)

angiogênese neoplasias vegf angiogenesis glândulas salivares anatomia patologica e patologia clinica tumors pdegf cd105 cd34 pdegf cd105 cd34 vegf salivary gland

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