Avaliação histologica do ligamento periodontal de ratos wistar sob efeito do hipotireoidismo agudo induzido pelo metimazol (Tapazol Marca Registrada ) / Evaluate the periodontal ligament under the effect of the acutely induced hypothyroidism

AUTOR(ES)
DATA DE PUBLICAÇÃO

2006

RESUMO

Objective ? Evaluate the periodontal ligament under the effect of the acutely induced hypothyroidism. Methods ? It was used 40 Wistar rats, which were separated in 2 groups of 20 animals each. The first group called ?treated?, that is, was induced to the hypothyroidism by the administration of methymazole 5 mg/100ml in the drinking water at will and the second one called ?control? in which it was not administered the methymazole. The thyroid condition has been evaluated by dosages of T4 in plasma, by the method of electrochemoluminescence of blood collected from the tail?s vain. Each group has been subdivided in impeded and unimpeded in relation to the eruption process and again subdivided, in relation to the euthanasia and collection of the material, in 21 and 28 days. As the rat presents the continuous grouth of the inferior incisors, the umpededing has been done under anesthetic effect by the cut of the left inferior incisor at the level of the interdental papillae each two days, this process of cut takes to the accelerated eruption of the tooth. In the 21st and 28th days it was done the euthanasia by anesthetic induction and the collection of material qualitative and quantitative histological analysis in which it was taken as parameters the cellularity; quantity and aspects of the collagen fibers and empty spaces. Results ? The qualitative analysis of the histological material has revealed differences among all the groups. Concerning to the quantitative analysis, there was difference statistically significant in relation to the number of the fibroblasts in region 5 between the impeded control and unimpeded treated groups, concerning to the empty space, the difference happened between the impeded control and unimpeded treated groups. When evaluated the condition of accelerated eruption it was found significant differences between the impeded control and unimpeded control groups, and it was not found differences between the impeded treated and unimpeded treated groups, showing this way that the hypothyroidism is a systemic condition that inhibits or minimizes the effects of the unimpeded in the acceleration of the dental eruption. Conclusion - All the groups have presented morphological differences when observed the microscopy. The alterations found are more dependent of the functional capacity of the involved cells than the increase or decrease of them. The effects of the hypothyroidism seem to inhibit or minimize the effects of the unimpeded in the stimulus of the increase of dental eruption speed

ASSUNTO(S)

metimazol methymazole periodontal ligament ligamento periodontal hipotireoidismo hypothyroidism

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