Bacterial Superantigen Exposure after Resolution of Influenza Virus Infection Perturbs the Virus-Specific Memory CD8+-T-Cell Repertoire
AUTOR(ES)
Huang, Chiu-Chen
FONTE
American Society for Microbiology
RESUMO
Heterologous viral infections have been shown to impact the preexisting memory CD8+-T-cell repertoire. Bacterial superantigens are products of common human pathogenic bacteria, including staphylococci and streptococci, that are potent T-cell-stimulatory molecules. In this report, we show that exposure to staphylococcal enterotoxin B, a bacterial superantigen, causes a selective functional deletion of cross-reactive influenza virus-specific CD8+ memory T cells. This perturbation of the memory repertoire can have a significant impact on viral clearance after secondary challenge.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=136287Documentos Relacionados
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