Bases moleculares dos efeitos da suplementação crônica com arginina sobre a sensibilidade à insulina: repercussões sobre os tecidos muscular esquelético, adiposo, hepático e sobre a secreção de insulina. / Molecular basis of the chronic effect of arginine supplementation on insulin sensitivity: repercussion in skeletal muscles, adipose tissue, liver and on insulin secretion.

AUTOR(ES)
DATA DE PUBLICAÇÃO

2010

RESUMO

Arginine (Arg) regulates the secretion of GH and insulin, and it is the main biological precursor of NO. We have previously shown that animals chronically-treated with Arg (35 mg/day) developed insulin resistance (IR), and this study investigated its molecular basis. The RI relies on the reduction of the activity and/or expression of IRS 1/2 and Akt, and of the GLUT4 content; and GH has a crucial role in the genesis of these effects. Higher doses of Arg (70 mg/dia/30 days), the increased NO generation and the improvement of the blood flow reversed the RI. Experiments with muscle cells showed that Arg stimulates glucose and lipids metabolism, via NO/c-GMP activation. These findings indicate that Arg may be beneficial for the treatment of metabolic disorders, such as obesity and T2DM, and by stimulating GH secretion, Arg can, in appropriate doses, be effective for the therapy of GH secretion disorders. However, further studies are needed to investigate the best dose and the chronic effects of Arg in vivo, since that GH in excess is potentially diabetogenic.

ASSUNTO(S)

arginina arginine glucose and lipid metabolism growth hormone hormônio do crescimento insulin resistance insulin secretion metabolismo de glicose e lipídeos nitric oxide Óxido nítrico resistência à insulina secreção de insulina

ACESSO AO ARTIGO

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