Benzoate catalysis in the hydrolysis of endo-5-[4′(5′)imidazolyl]-bicyclo[2.2.1]hept-endo- 2-yl trans-cinnamate: Implications for the charge-transfer mechanism of catalysis by serine proteases
AUTOR(ES)
Roberts, John D.
RESUMO
The acceleration, by a factor of 2500, of the hydrolysis of endo-5-[4′(5′)imidazolyl]bicyclo[2.2.1]hept-endo- 2-yl trans-cinnamate by 0.5 M sodium benzoate in 42 mol% dioxane in water can be explained without resort to operation of a “charge-relay” mechanism similar to that often postulated to account for the enzymatic activity of serine proteases. The degree of ionization of 4-methylimidazole and of sodium benzoate in 42 mol% dioxane in water at 60°C have been measured by NMR spectroscopy.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=349558Documentos Relacionados
- Polarons and excitons in charge-transfer systems
- Role of charge-transfer states in bacterial photosynthesis
- QUANTUM CHEMICAL STUDIES OF CHARGE-TRANSFER COMPLEXES OF INDOLES*
- Disulfide bond formation involves a quinhydrone-type charge–transfer complex
- Tunneling in Chromatium chromatophores: Detection of a Hopfield charge-transfer band