beta-Endorphin: synthesis of analogs modified at the carboxyl terminus with increased activites.
AUTOR(ES)
Li, C H
RESUMO
Three analogs of human beta-endorphin (beta h-EP) have been synthesized: [Gly31]beta h-EP, [Gly31]beta h-endorphinamide, and [Gly31]beta h-endorphinylglycine. All are more active than beta h-EP in both the guinea pig ileum bioassay and the opiate receptor binding assay. The last two analogs are about twice as active as beta h-EP in an assay for analgesia. Modification at position 31 and extension at the COOH terminus may afford a route toward analogs with even greater biological activity.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=383807Documentos Relacionados
- beta-Endorphin: behavioral and analgesic activity in cats.
- beta-Endorphin: formation of alpha-helix in lipid solutions.
- Beta-endorphin: stimulation of growth hormone release in vivo.
- beta-Endorphin: surface binding and internalization in thymoma cells.
- beta-Endorphin: pituitary and adrenal glands modulate its action.