Bidirectional plasticity of excitatory postsynaptic potential (EPSP)-spike coupling in CA1 hippocampal pyramidal neurons
AUTOR(ES)
Daoudal, Gaël
FONTE
National Academy of Sciences
RESUMO
Integration of synaptic excitation to generate an action potential (excitatory postsynaptic potential-spike coupling or E-S coupling) determines the neuronal output. Bidirectional synaptic plasticity is well established in the hippocampus, but whether active synaptic integration can display potentiation and depression remains unclear. We show here that synaptic depression is associated with an N-methyl-d-aspartate receptor-dependent and long-lasting depression of E-S coupling. E-S depression is input-specific and is expressed in the presence of γ-aminobutyric acid type A and B receptor antagonists. In single neurons, E-S depression is observed without modification of postsynaptic passive properties. We conclude that a decrease in intrinsic excitability underlies E-S depression and is synergic with glutamatergic long-term depression.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=137914Documentos Relacionados
- Active summation of excitatory postsynaptic potentials in hippocampal CA3 pyramidal neurons
- Operative GABAergic inhibition in hippocampal CA1 pyramidal neurons in experimental epilepsy
- Dendritic glutamate receptor channels in rat hippocampal CA3 and CA1 pyramidal neurons.
- Spike after-depolarization and burst generation in adult rat hippocampal CA1 pyramidal cells.
- Ionic basis of spike after-depolarization and burst generation in adult rat hippocampal CA1 pyramidal cells.