Biliary and pancreatic excretion of cefamandole.
AUTOR(ES)
Burns, G P
RESUMO
After intravenous infusion of secretin and cholecystokinin in six dogs, cefamandole (50 mg/kg of body weight) was given intravenously for 10 min. Samples of serum, bile, pancreatic juice, liver, pancreas, fat, and muscle were collected over a 2-h period. Cefamandole levels were measured by a microbiological assay. The highest levels were as follows: serum, 160 micrograms/ml; bile, 3,071 micrograms/ml; pancreatic juice, 7 micrograms/ml; liver, 101 micrograms/g; pancreas, 44 micrograms/g; muscle, 20 micrograms/g; and fat, 14 micrograms/g. Levels in pancreatic juice were extremely low compared with levels in pancreatic tissue, suggesting the existence of a barrier to excretion at the ductal membrane.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=284269Documentos Relacionados
- Comparative pharmacokinetics of cefoperazone and cefamandole.
- Treatment of typhoid fever with cefamandole.
- Decreased biliary excretion of cefamandole after percutaneous biliary decompression in patients with total common bile duct obstruction.
- Pharmacology of ceftizoxime compared with that of cefamandole.
- In vitro and in vivo studies with BL-S786, cefoxitin, and cefamandole.