Biotechnological Properties of Sponges from Northeast Brazil: Cliona varians as a Biocatalyst for Enantioselective Reduction of Carbonyl Compounds
AUTOR(ES)
Riatto, Valéria B.
FONTE
J. Braz. Chem. Soc.
DATA DE PUBLICAÇÃO
2019-01
RESUMO
To research the potential ability of whole marine sponges to act as biocatalysts, this paper describes for the first time the employment of whole Cliona varians sponge in the stereoselective reduction of prochiral a-keto esters and isatin to the corresponding chiral alcohols. The addition of D-fructose, D-glucose or sucrose remarkably increased the conversion ratios and stereoselectivities by this marine sponge. Furthermore, in the presence of D-glucose and D-maltose, the reduction of isatin by C. varians afforded the corresponding 3-hydroxyindolin-2-one with high conversions (85-90%) and good enantioselectivities (60-74%). These results showed that the marine sponge presents great potential to be used as biocatalyst for stereoselective reduction of carbonyl compounds.
Documentos Relacionados
- Radical mechanisms for 1,5-dihydroflavin reduction of carbonyl compounds.
- Ecology and biotechnological potential of bacterial community from three marine sponges of the coast of Rio de Janeiro, Brazil
- O-nitroso aldol synthesis: Catalytic enantioselective route to α-aminooxy carbonyl compounds via enamine intermediate
- Efeito pró-inflamatório de uma lectina purificada da esponja marinha Cliona varians
- Inbreeding levels in Northeast Brazil: strategies for the prospecting of new genetic disorders