Birth pangs: the stressful origins of lymphocytes

AUTOR(ES)

Pillai, Shiv

FONTE

American Society for Clinical Investigation

RESUMO

Inositol-requiring enzyme 1 (IRE1) is a transmembrane protein that signals from the ER and contributes to the generation of an active spliced form of the transcriptional regulator X-box–binding protein 1 (XBP1). XBP1 is required for the terminal differentiation of B lymphocytes into plasma cells, and IRE1 also participates in this differentiation event. A study in this issue of the JCI reveals, quite unexpectedly, that IRE1 is also required early in B lymphocyte development for the induction of the machinery that mediates Ig gene rearrangement.

Documentos Relacionados

• Impact of stressful life events on central adiposity in the Pelotas Birth Cohort
• Testosterone in utero and at birth dictates how stressful experience will affect learning in adulthood
• The fetal origins hypothesis—10 years on: Events before birth remain important, but we need to consider later modifiers too
• The origins of sympathectomy.
• THE ORIGINS OF LIFE