Brazilian propolis protects Saccharomyces cerevisiae cells against oxidative stress

AUTOR(ES)

Sá, Rafael A. de, Castro, Frederico A.V. de, Eleutherio, Elis C.A., Souza, Raquel M. de, Silva, Joaquim F.M. da, Pereira, Marcos D.

FONTE

Braz. J. Microbiol.

DATA DE PUBLICAÇÃO

17/12/2013

RESUMO

Propolis is a natural product widely used for humans. Due to its complex composition, a number of applications (antimicrobial, antiinflammatory, anesthetic, cytostatic and antioxidant) have been attributed to this substance. Using Saccharomyces cerevisiae as a eukaryotic model we investigated the mechanisms underlying the antioxidant effect of propolis from Guarapari against oxidative stress. Submitting a wild type (BY4741) and antioxidant deficient strains (ctt1∆, sod1∆, gsh1∆, gtt1∆ and gtt2∆) either to 15 mM menadione or to 2 mM hydrogen peroxide during 60 min, we observed that all strains, except the mutant sod1∆, acquired tolerance when previously treated with 25 µg/mL of alcoholic propolis extract. Such a treatment reduced the levels of ROS generation and of lipid peroxidation, after oxidative stress. The increase in Cu/Zn-Sod activity by propolis suggests that the protection might be acting synergistically with Cu/Zn-Sod.

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