Calmodulin activation of plant microsomal Ca2+ uptake

AUTOR(ES)

Dieter, Peter

RESUMO

The active ATP-dependent uptake of Ca2+ into a plasma membrane-enriched microsomal fraction from plants is stimulated by the addition of plant as well as bovine brain calmodulin. This stimulation occurs only when the microsomes are prepared in the presence of EDTA. Plant calmodulin also activates the bovine brain 3′,5′-cyclic-nucleotide phosphodiesterase (EC 3.1.4.17). Mitochondrial Ca2+ accumulation is not affected by calmodulin. The calmodulin-mediated activation of microsomal Ca2+ uptake is abolished by the antipsychotic drug fluphenazine, whereas the calmodulin-independent Ca2+ uptake is only slightly decreased.

Documentos Relacionados

• Activation of plant quinate:NAD+ 3-oxidoreductase by Ca2+ and calmodulin
• ATP-dependent Ca2+ uptake into plant membrane vesicles
• Calmodulin activation and inhibition of skeletal muscle Ca2+ release channel (ryanodine receptor).
• Store-operated Ca2+ entry depends on mitochondrial Ca2+ uptake
• Direct comparison of Ca2+ requirements for calmodulin interaction with and activation of protein phosphatase.