Capacity of a cis-diammineplatinum[II]-polyglutamic acid complex to cure Trypanosoma congolense infections in mice.
AUTOR(ES)
Meshnick, S R
RESUMO
A cis-diammineplatinum(II)-polyglutamic acid complex proved to have marked trypanocidal activity in vivo. When 5 mg of platinum per kg was administered daily for 5 days or when 20 mg of platinum per kg was administered on days 1, 3, and 6, five of five treated Trypanosoma congolense-infected mice were cured. In contrast, cis-platin was ineffective at all doses tested. We believe that the complex has a much higher therapeutic ratio than does uncomplexed drug because it is less toxic.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=185493Documentos Relacionados
- Genetic resistance to Trypanosoma congolense infections in mice.
- Autoimmunity in Experimental Trypanosoma congolense Infections of Rabbits 1
- Characterization of antibodies mediating protection and cure of Trypanosoma musculi infection in mice.
- Cure of Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense infections in mice with an irreversible inhibitor of S-adenosylmethionine decarboxylase.
- Amphotericin B lipid complex therapy of experimental fungal infections in mice.
