Carbohydrate-specified endocytosis: localization of ligand in the lysosomal compartment.

AUTOR(ES)

Haimes, H B

RESUMO

Carbohydrate-directed endocytosis is mediated by a receptor, the hepatic binding protein; it is responsible for the clearance of galactose-terminated glycoproteins from the circulation. This process was investigated by using lactosaminated ferritin which is recognized by this receptor. Ferritin was seen in elements of an extensive "lysosomal compartment" that includes secretory vacuoles, coated vesicles, and GERL. The compartment marked in hepatocytes by the distribution of ligand is similar to that previously described in Kupffer cells (marked by acid phosphatase reaction product and horseradish peroxidase reaction product).

Documentos Relacionados

• Comparative studies on the electrical properties of the H+ translocating ATPase and pyrophosphatase of the vacuolar-lysosomal compartment.
• Receptor-mediated endocytosis of transferrin and the uptake of fe in K562 cells: identification of a nonlysosomal acidic compartment.
• The agent of Human Granulocytic Ehrlichiosis resides in an endosomal compartment.
• Receptor-mediated endocytosis: insights from the lipoprotein receptor system.
• Folding and oligomerization of influenza hemagglutinin in the ER and the intermediate compartment.