Carboxyhaemoglobin and pulmonary epithelial permeability in man.
AUTOR(ES)
Jones, J G
RESUMO
The effect of cigarette smoke exposure on pulmonary epithelial permeability was studied in 45 smokers and 22 non-smokers. An index of cigarette smoke exposure was obtained from the carboxyhaemoglobin concentration (HbCO%). Pulmonary epithelial permeability was proportional to the half-time clearance rate of technetium-99m-labelled diethylene triamine pentacetate (99mTc DTPA) from lung to blood (T1/2LB). The relationship between T1/2LB and HbCO% was hyperbolic in form and the data could be fitted to the quadratic formula (formula; see text) where the parameters a0, a1, and a2 represent respectively the asymptotic T1/2LB value at large carboxyhaemoglobin values and the slope and shape of the curve. The values of these parameters were a0 4.4 (2.6), a1 = 77.8 (15.5), and a2 -25.5 (9.7) (SE). This is the first demonstration of a dose-response relationship between carboxyhaemoglobin and an increased permeability of the lungs in man and provides a technique for identifying the roles of carbon monoxide and other cigarette smoke constituents in causing increased pulmonary epithelial permeability.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=459501Documentos Relacionados
- Pulmonary absorption and elimination of ethylene glycol monoethyl ether acetate in man.
- Noninvasive measurement of pulmonary transvascular protein flux in normal man.
- Recording of left atrial potentials from pulmonary artery in man.
- Effects of adrenergic blockade on the pulmonary circulation in man.
- Regional distribution of pulmonary epithelial permeability in normal subjects and patients with asbestosis.