CD4+ Lymphocyte-Mediated Suppression of Cytomegalovirus Expression in Human Astrocytes

AUTOR(ES)

Cheeran, Maxim C.-J.

FONTE

American Society for Microbiology

RESUMO

Cytomegalovirus-stimulated CD4+ lymphocytes from seropositive but not seronegative donors suppressed viral gene expression in primary human astrocytes. This suppressive activity was mediated through soluble factors. These findings suggest that CD4+ lymphocytes play a role in defense of the brain against cytomegalovirus.

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