Cell type-specific interactions of transcription factors with a housekeeping promoter in vivo.

AUTOR(ES)

Stapleton, G

RESUMO

Mammalian housekeeping promoters represent a class of regulatory elements different from those of tissues-specific genes, lacking a TATA box and associated with CG-rich DNA. We have compared the organization of the housekeeping Htf9 promoter in different cell types by genomic footprinting. The sites of in vivo occupancy clearly reflected local combinations of tissue-specific and ubiquitous binding factors. The flexibility of the Htf9 promoter in acting as the target of cell-specific combinations of factors may ensure ubiquitous expression of the Htf9-associated genes.

Documentos Relacionados

• Housekeeping Na,K-ATPase alpha 1 subunit gene promoter is composed of multiple cis elements to which common and cell type-specific factors bind.
• Multiple interdependent regulatory sites in the mouse c-fos promoter determine basal level transcription: cell type-specific effects.
• Cell type-specific MxA-mediated inhibition of measles virus transcription in human brain cells.
• Cell type-specific transcriptional enhancement in vitro requires the presence of trans-acting factors.
• Monocytic cell type-specific transcriptional induction of collagenase.