Cells Producing Low-Molecular-Weight Antibody to Escherichia coli Lipopolysaccharide

AUTOR(ES)

Jackson, Anne L.

RESUMO

CD-1 mice immunized with sheep red blood cells (SRBC) or Escherichia coli lipopolysaccharide (LPS), developed splenic plaque-forming cells (PFC) producing low-molecular-weight antibody; these cells were detected by means of purified rabbit antisera to mouse γ1, γ2a, and γ2b immunoglobulins. In contrast to SRBC, the primary γ1 response to LPS was absent and γ2a and γ2b PFC were detected irregularly. Both immunogens elicited a secondary cellular response in all three subclasses without a corresponding increase in “direct” or γM PFC. An increase in serum bactericidal antibody following a second injection of LPS was not parallelled by an increase in splenic γM PFC; it might therefore involve the synthesis of γ2 complement-fixing antibody.

Documentos Relacionados

• LOW-MOLECULAR-WEIGHT RHEUMATOID FACTOR*
• Characterization of a novel, low-molecular-weight DNA-binding protein from Escherichia coli.
• Antibody response to low-molecular-weight antigens of Aspergillus fumigatus in allergic bronchopulmonary aspergillosis.
• Low-molecular-weight xylanase from Trichoderma viride.
• Evidence for a low-molecular-weight collagen precursor.