Characterization of a mutation in the parE gene that confers fluoroquinolone resistance in Streptococcus pneumoniae.
AUTOR(ES)
Perichon, B
RESUMO
We report a mutation in the parE genes of two in vitro mutants of Streptococcus pneumoniae responsible for low-level resistance to fluoroquinolones. Sequential acquisition of mutations in parE and gyrA leads to higher levels of resistance. This confirms that topoisomerase IV is the primary target of fluoroquinolones in S. pneumoniae.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=163872Documentos Relacionados
- Cloning and characterization of the parC and parE genes of Streptococcus pneumoniae encoding DNA topoisomerase IV: role in fluoroquinolone resistance.
- Apparent involvement of a multidrug transporter in the fluoroquinolone resistance of Streptococcus pneumoniae.
- Mutations in the gyrA, parC, and parE Genes Associated with Fluoroquinolone Resistance in Clinical Isolates of Mycoplasma hominis
- Molecular characterization of the Salmonella typhimurium parE gene.
- Activities of Newer Fluoroquinolones against Streptococcus pneumoniae Clinical Isolates Including Those with Mutations in the gyrA, parC, and parE Loci
