Characterization of a myc-containing retrovirus generated by propagation of an MH2 viral subgenomic RNA.
AUTOR(ES)
Martin, P
RESUMO
We have previously isolated, from wild-type MH2 virus that contains the two oncogenes mil and myc, mutants defective in one or the other oncogene product. We report here the molecular cloning and extensive characterization of MH2 CL25 provirus lacking the v-mil oncogene. Our results indicate that this virus corresponds to the propagation of the 2.8-kilobase subgenomic RNA of MH21.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=252859Documentos Relacionados
- RNA and protein encoded by MH2 virus: evidence for subgenomic expression of v-myc.
- Transforming variants of the avian myc-containing retrovirus FH3 arise prior to phenotypic selection.
- In vitro-derived leukemic erythroid cell lines induced by a raf- and myc-containing retrovirus differentiate in response to erythropoietin.
- Insertional mutagenesis of flvi-2 in tumors induced by infection with LC-FeLV, a myc-containing strain of feline leukemia virus.
- Tumorigenic potential of a myc-containing strain of feline leukemia virus in vivo in domestic cats.