Characterization of endonuclease III (nth) and endonuclease VIII (nei) mutants of Escherichia coli K-12.
AUTOR(ES)
Saito, Y
RESUMO
The nth and nei genes of Escherichia coli affect the production of endonuclease III and endonuclease VIII, respectively, glycosylases/apurinic lyases that attack DNA damaged by oxidizing agents. Here, we provide evidence that oxidative lethal lesions are repaired by both endonuclease III and endonuclease VIII and that spontaneous mutagenic lesions are repaired mainly by endonuclease III.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=179178Documentos Relacionados
- Endonuclease III (nth) mutants of Escherichia coli.
- Escherichia coli endonuclease VIII: cloning, sequencing, and overexpression of the nei structural gene and characterization of nei and nei nth mutants.
- Genetic mapping of nth, a gene affecting endonuclease III (thymine glycol-DNA glycosylase) in Escherichia coli K-12.
- Isolation and characterization of norfloxacin-resistant mutants of Escherichia coli K-12.
- Isolation and characterization of respiratory-deficient mutants of Escherichia coli K-12.
