Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line.

AUTOR(ES)

Drivas, G T

RESUMO

A mixed-oligonucleotide probe was used to identify four ras-like coding sequences in a human teratocarcinoma cDNA library. Two of these sequences resembled the rho genes, one was closely related to H-, K-, and N-ras, and one shared only the four sequence domains that define the ras gene superfamily. Homologs of the four genes were found in genomic DNA from a variety of mammals and from chicken. The genes were transcriptionally active in a range of human cell types.

Documentos Relacionados

• RIC, a calmodulin-binding Ras-like GTPase.
• The Ras-like GTPase Gem is involved in cell shape remodelling and interacts with the novel kinesin-like protein KIF9
• Transcriptional activation of a ras-like gene (kir) by oncogenic tyrosine kinases.
• Interaction cloning of Rabin3, a novel protein that associates with the Ras-like GTPase Rab3A.
• The ras-like protein p25rab3A is partially cytosolic and is expressed only in neural tissue.