Charge movement in skeletal muscle fibers paralyzed by the calcium-entry blocker D600.
AUTOR(ES)
Hui, C S
RESUMO
We report measurements of nonlinear charge movement in frog skeletal muscle fibers paralyzed by the calcium-entry blocker [Schwartz, A. & Taira, N., eds. (1983) Circ. Res. 52, Part II, Number 2, 1-181.] D600 (methoxyverapamil, recently renamed gallopamil). Nonlinear charge movement was not seen in such fibers, suggesting that the drug severs the link between membrane depolarization and the main components of charge movement. This is the only pharmacological agent that blocks the main components of charge movement.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=345107Documentos Relacionados
- Ryanodine interferes with charge movement repriming in amphibian skeletal muscle fibers.
- Paralysis of frog skeletal muscle fibres by the calcium antagonist D-600.
- Intramembrane charge movement and calcium release in frog skeletal muscle.
- Calcium current activation and charge movement in denervated mammalian skeletal muscle fibres.
- Effects of tetracaine on charge movements and calcium signals in frog skeletal muscle fibers