Chemical composition and analgesic activity of the leaves and branches of Marlierea tomentosa Camb.
AUTOR(ES)
Messias, Karina Louise S., Campos-Buzzi, Fátima de, Fischer, Luiz G. O., Malheiros, Ângela, Delle Monache, Franco, Cechinel Filho, Valdir
FONTE
Química Nova
DATA DE PUBLICAÇÃO
2008
RESUMO
This paper describes the isolation of five phytoconstituents from Marlierea tomentosa. The triterpenes α-amyrin (1) and β-amyrin (2), and the flavonoids quercitrin (3) and isoquercetin (4), were isolated from the leaves. The branches afforded the triterpene arjunolic acid (5). The antinociceptive activity of crude extract, fractions and compound 5 were tested using the writhing and formalin tests in mice. The crude extract, some fractions, particularly dichloromethane and butanol (leaves), ethyl acetate (branches) and arjunolic acid (5) (81.2% inhibition) were more active against the writhing test than the two reference drugs, acetylsalicylic acid and indomethacin.
Documentos Relacionados
- Chemical composition and cytotoxic activity of the essential oil from the leaves of Casearia lasiophylla
- Chemical and agronomic development of Kalanchoe brasiliensis Camb. and Kalanchoe pinnata (Lamk.) Pers under light and temperature levels
- Topical antiinflammatory activity and chemical composition of the epicuticular wax from the leaves of Eugenia beaurepaireana (Myrtaceae)
- CHEMICAL COMPOSITION VARIABILITY IN THE Uncaria tomentosa (cat’s claw) WILD POPULATION
- Antiproliferative activity, antioxidant capacity and chemical composition of extracts from the leaves and stem of Chresta sphaerocephala