Chemical composition and effect of an essential oil of Salix aegyptiaca L., Salicaceae, (musk willow) in hypercholesterolemic rabbit model
AUTOR(ES)
Karimi, Isaac, Hayatgheybi, Hossein, shamspur, Tayebeh, Kamalak, Adem, Pooyanmehr, Mehrdad, Marandi, Yaser
FONTE
Revista Brasileira de Farmacognosia
DATA DE PUBLICAÇÃO
04/03/2011
RESUMO
The essential oils (EO) of Salix aegyptiaca L., Salicaceae (SA), leaves were extracted using the hydrodistillation method and their chemical composition was further determined by GC-MS. 1,4-Dimethoxybenzene was the main isolated compound. Other major isolated constitutes were phenylethyl alcohol, carvone, citronellol, methyleugenol, eugenol, n-tetradecane and 4'-methoxyacetophenone. Twenty rabbits were equally divided into four groups: Normal control (NC) which fed a standard diet and three cholesterol-fed groups: HC, HC+1.0% SA and HC+3.0% SA groups which received 0.0%, 1.0% and 3.0% EO, respectively for four weeks. The serum lipid and lipoprotein profiles and atherogenic index (AI) were measured weekly. The high cholesterol diet significantly raised the TC, LDL-C, VLDL-C, HDL-C, TG and AI level compared with NC group. HC+1.0% SA and HC+3.0% SA groups showed similar results compared with HC group. It can be concluded that the EO of SA leaves could not prevent dyslipidemia that occurred in rabbits following inclusion of cholesterol in diet in both dose-and time-dependent manners.
Documentos Relacionados
- ESSENTIAL OIL OF CURCUMA LONGA L. RHIZOMES CHEMICAL COMPOSITION, YIELD VARIATION AND STABILITY
- Chemical composition and antimicrobial activity of the essential oil of Hyptis pectinata (l.) Poit.
- Effect of season and irrigation on the chemical composition of Aloysia triphylla essential oil
- Chemical Composition and Antibacterial Activity of the Essential Oil of Vitex agnus-castus L. (Lamiaceae)
- Chemical composition and histochemistry of Sphagneticola trilobata essential oil