Chemical incorporation of 1-methyladenosine into oligonucleotides
AUTOR(ES)
Mikhailov, Sergey N.
FONTE
Oxford University Press
RESUMO
The base moiety of 1-N-methyladenosine can be protected with a chloroacetyl group for incorporation of this modified nucleoside into DNA and RNA. Carefully controlled anhydrous conditions are needed for deprotection of the oligonucleotides.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=101250Documentos Relacionados
- Occurrence of 1-methyladenosine and absence of ribothymidine in transfer ribonucleic acid of Mycobacterium smegmatis.
- Incorporation of terminal phosphorothioates into oligonucleotides.
- The essential Gcd10p–Gcd14p nuclear complex is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA
- Evidence for en bloc incorporation of exogenous oligonucleotides into HeLa cell RNA.
- Incorporation by chemical synthesis and characterization of deoxyribosylformylamine into DNA.
